The Adverse Event Paradox




Adverse Event, Placebo Effect, Nocebo Effect, Randomized Controlled Trials


Beigel, John H., Kay M. Tomashek, Lori E. Dodd, Aneesh K. Mehta, Barry S. Zingman, Andre C. Kalil, Elizabeth Hohmann, et al. 2020. “Remdesivir for the Treatment of Covid-19: Final Report.” New England Journal of Medicine 383, no. 19: 1813–1826.

Bolton, Monica, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste, and Harm van Marwijk. 2019. “Serious Adverse Events Reported in Placebo Randomised Controlled Trials of Oral Naltrexone: A Systematic Review and Meta-Analysis.” BMC Medicine 17, no. 1: 1–13.

Colloca, Luana and Franklin G. Miller. 2011. “The Nocebo Effect and Its Relevance for Clinical Practice.” Psychosomatic Medicine 73, no. 7: 598–603.

Hammond, Jennifer, Heidi Leister-Tebbe, Annie Gardner, Paula Abreu, Weihang Bao, Wayne Wisemandle, MaryLynn Baniecki, et al. 2022. “Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.” New England Journal of Medicine 386, no. 15: 1397–1408.

Kirsch, Irving. 2010. The Emperor’s New Drugs: Exploding the Antidepressant Myth. New York: Basic Books.

Wang, Yeming, Dingyu Zhang, Guanhua Du, Ronghui Du, Jianping Zhao, Yang Jin, Shouzhi Fu, et al. 2020. “Remdesivir in Adults with Severe COVID-19: A Randomised, Double-Blind, Placebo-Controlled, Multicentre Trial.” The Lancet 395, no. 10236: 1569–1578.




How to Cite

Milovac, T. (2022). The Adverse Event Paradox . Philosophy of Medicine, 3(1).