Interventional Philosophy in Medicine

Formulating Hypotheses

Authors

  • Timothy Daly Department of Philosophy, Sorbonne Université, Paris, France; Bioethics Program, FLACSO, Buenos Aires, Argentina https://orcid.org/0000-0003-1650-242X

DOI:

https://doi.org/10.5195/pom.2024.179

Keywords:

Amyloid, Alzheimer's disease, Proteinopenia, Philosophy in science, Philosophy in medicine

References

Daly, Timothy. 2023. “Learning from the Amyloid Hypothesis: Adaptability, Brevity, and Clarity of Ideas.” Neurological Sciences 44, no. 6: 2177–2178. https://doi.org/10.1007/s10072-023-06745-5.

Daly, Timothy, Vincent Henry, and Mathieu Bourdenx. 2023. “From Association to Intervention: The Alzheimer’s Disease-Associated Processes and Targets (ADAPT) Ontology.” Journal of Alzheimer’s Disease 94, no. S1: S87–S96. https://doi.org/10.3233/jad-221004.

Espay, Alberto J., Karl Herrup, Kasper P. Kepp, and Timothy Daly. 2023. “The Proteinopenia Hypothesis: Loss of Aβ42 and the Onset of Alzheimer’s Disease.” Ageing Research Reviews 92, article 102112. https://doi.org/10.1016/j.arr.2023.102112.

Espay, Alberto J. and Michael S. Okun. 2023. “Abandoning the Proteinopathy Paradigm in Parkinson Disease.” JAMA Neurology 80, no. 2: 123–124. https://doi.org/10.1001/jamaneurol.2022.4193.

Hardy, John. 2006. “Alzheimer’s Disease: The Amyloid Cascade Hypothesis—An Update and Reappraisal.” Journal of Alzheimer’s Disease 9, no. S3: S151–S153. https://doi.org/10.3233/jad-2006-9s317.

Hardy, John A. and Gerald A. Higgins. 1992. “Alzheimer’s Disease: The Amyloid Cascade Hypothesis.” Science 256, no. 5054: 184–185. https://doi.org/10.1126/science.1566067.

Herrup, Karl. 2015. “The Case for Rejecting the Amyloid Cascade Hypothesis.” Nature Neuroscience 18, no. 6: 794–799. https://doi.org/10.1038/nn.4017.

Kepp, Kasper P., Nikolaos K. Robakis, Poul F. Høilund-Carlsen, Stefano L. Sensi, and Bryce Vissel. 2023. “The Amyloid Cascade Hypothesis: An Updated Critical Review.” Brain 146, no. 10: 3969–3990. https://doi.org/10.1093/brain/awad159.

Kuhn, Thomas S. 1970. The Structure of Scientific Revolutions. Chicago: University of Chicago Press.

Pradeu, Thomas, Sébastien Jaeger, and Eric Vivier. 2013. “The Speed of Change: Towards a Discontinuity Theory of Immunity?” Nature Reviews Immunology 13, no. 10: 764–769. https://doi.org/10.1038/nri3521.

Pradeu, Thomas, Maël Lemoine, Mahdi Khelfaoui, and Yves Gingras. 2021. “Philosophy in Science: Can Philosophers of Science Permeate through Science and Produce Scientific Knowledge?” British Journal of Philosophy of Science. https://doi.org/10.1086/715518.

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Published

2024-05-09

How to Cite

Daly, T. (2024). Interventional Philosophy in Medicine: Formulating Hypotheses. Philosophy of Medicine, 5(1). https://doi.org/10.5195/pom.2024.179

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Section

Letters