Interventional Philosophy in Medicine

Formulating Hypotheses


  • Timothy Daly Department of Philosophy, Sorbonne Université, Paris, France; Bioethics Program, FLACSO, Buenos Aires, Argentina



Amyloid, Alzheimer's disease, Proteinopenia, Philosophy in science, Philosophy in medicine


Daly, Timothy. 2023. “Learning from the Amyloid Hypothesis: Adaptability, Brevity, and Clarity of Ideas.” Neurological Sciences 44, no. 6: 2177–2178.

Daly, Timothy, Vincent Henry, and Mathieu Bourdenx. 2023. “From Association to Intervention: The Alzheimer’s Disease-Associated Processes and Targets (ADAPT) Ontology.” Journal of Alzheimer’s Disease 94, no. S1: S87–S96.

Espay, Alberto J., Karl Herrup, Kasper P. Kepp, and Timothy Daly. 2023. “The Proteinopenia Hypothesis: Loss of Aβ42 and the Onset of Alzheimer’s Disease.” Ageing Research Reviews 92, article 102112.

Espay, Alberto J. and Michael S. Okun. 2023. “Abandoning the Proteinopathy Paradigm in Parkinson Disease.” JAMA Neurology 80, no. 2: 123–124.

Hardy, John. 2006. “Alzheimer’s Disease: The Amyloid Cascade Hypothesis—An Update and Reappraisal.” Journal of Alzheimer’s Disease 9, no. S3: S151–S153.

Hardy, John A. and Gerald A. Higgins. 1992. “Alzheimer’s Disease: The Amyloid Cascade Hypothesis.” Science 256, no. 5054: 184–185.

Herrup, Karl. 2015. “The Case for Rejecting the Amyloid Cascade Hypothesis.” Nature Neuroscience 18, no. 6: 794–799.

Kepp, Kasper P., Nikolaos K. Robakis, Poul F. Høilund-Carlsen, Stefano L. Sensi, and Bryce Vissel. 2023. “The Amyloid Cascade Hypothesis: An Updated Critical Review.” Brain 146, no. 10: 3969–3990.

Kuhn, Thomas S. 1970. The Structure of Scientific Revolutions. Chicago: University of Chicago Press.

Pradeu, Thomas, Sébastien Jaeger, and Eric Vivier. 2013. “The Speed of Change: Towards a Discontinuity Theory of Immunity?” Nature Reviews Immunology 13, no. 10: 764–769.

Pradeu, Thomas, Maël Lemoine, Mahdi Khelfaoui, and Yves Gingras. 2021. “Philosophy in Science: Can Philosophers of Science Permeate through Science and Produce Scientific Knowledge?” British Journal of Philosophy of Science.




How to Cite

Daly, T. (2024). Interventional Philosophy in Medicine: Formulating Hypotheses. Philosophy of Medicine, 5(1).